Lyric discussion by DJ LM 

Cover art for Casandra's Ire lyrics by New Silent Generation, The

The title "Cassadra's Ire" refers to two things. One being anger and scorn (denoted by the word "Ire"). The second being the reference to Cassandra, who was blessed with precognition but cursed to never be believed.

The lyrics reference someone who has apparently tried to save a group from themselves, but has become irritated that their words fall on deaf ears. It is then that the speaker seems to embrace the futility of trying to save them and relishes in their contribution to natural selection.

Everything should make sense now.