Lyric discussion by Zizzle 

Cover art for Mexicola lyrics by Queens of the Stone Age

This song is about mortality and excess and the rock'n roll lifestyle.

"Setting sun deals hands of gold" Gambling reference. Or refernce to the role of chance in life.

"Speak in tongues, speak in lies" The music industry is not the most honest.

"Drooling livers, born to die" Alcohol damages your liver. Josh and Nick don't mind a drop.

"Keep sayin, go on, keep sayin, go on, keep sayin, you will live forever" Delude yourself that you can survive the excess of the lifestyle.

"One dog's dead one's on the phone" His doctor or a record company exec?

"Just leave a lung or leave it alone" Smoking damages lungs and they smoke.

"It's that same on song again I hate it cause it's true"

He hates hearing about the damage he is doing to himself.