Lyric discussion by mamberso 

Cover art for Hazard lyrics by Richard Marx

Song obviously about the death of Mary under tragic, but blatant circumstances. The narrator indicates the prejudice against him, and that it seems to play into the fact that he is whom everyone suspects as Mary's killer. However, if you look closely at the last two line of the chorus, he seems to indicate contemplating suicide. Possibly due to a guilty conscience.

No, it is not due to a guilty conscience. He is living in a town were there was only one person who cared for or about him and it is strongly implied that he loved her. Then suddenly she dies, and everyone accusses him of killing her. Who in or out of their right mind would want to stay under those circumstances?!?

"I need to make it to the river and leave this old Nebraska town" could easily indicate that he wants to follow the river out of town. Many towns have roadways that follow or cross the river to enter and exit. It could also indicate that he wants to visit the river to mourn Mary's loss and then leave (as he does in the video). Even if he did want to commit suicide, it wouldn't necessarily be because he was guilty. (See arthurn's comment.)

@mamberso I believe he may be suicidal, but not due to guilt, but because he loved Mary and she was the only person who saw who he really was as a human being.