Lyric discussion by HardRocker7 

Cover art for Frogs lyrics by Alice in Chains

how the hell would u get drug abuse outta this?! my god its clearly about friendships goin throught rough times!!! just cuz layne was on heroin doesnt mean that all their damn music is abt it

Actually it could very easily be an allusion to both. Many, addicts become so deeply codependent on the drugs that in their minds, they attribute the euphoria with a relationship and come to view them almost as a friend. When that friend eventually starts to kill you, you can't feel to an altered mind, that wouldn't feel like a betrayal?