Lyric discussion by starflyer79 

Cover art for Hometown lyrics by Twenty One Pilots

There are some pretty blatant biblical allusions here:

"Put away, put away all the gods your father served today Put away, put away your traditions, believe me when I say"

Now therefore fear the LORD, and serve him in sincerity and in truth: and put away the gods which your fathers served on the other side of the flood, and in Egypt; and serve ye the LORD. - Joshua 24:14 KJV

...

"Be the one, be the one to take my soul and make it undone Be the one, be the one to take me home and show me the sun"

Then said I, Woe is me! for I am undone; because I am a man of unclean lips, and I dwell in the midst of a people of unclean lips: for mine eyes have seen the King, the LORD of hosts. - Isaiah 6:5 KJV

I know, I know You can bring the fire, I can bring the bones I know, I know You make the fire in my bones, and make it grow"

Then I said, I will not make mention of him, nor speak any more in his name. But his word was in mine heart as a burning fire shut up in my bones, and I was weary with forbearing, and I could not stay. - Jeremiah 20:9 KJV

...

As for the chorus:

Where we're from We're no one Our hometown's in the dark

And they were deeply offended and refused to believe in him. Then Jesus told them, "A prophet is honored everywhere except in his own hometown and among his own family." - Matthew 13:57 NLT

Saying, If thou hadst known, even thou, at least in this thy day, the things which belong unto thy peace! but now they are hid from thine eyes. - Luke 19:42 NLT