Lyric discussion by obstacle2 

Cover art for Despair lyrics by Yeah Yeah Yeahs

I actually see this song as a comforting to someone who feels slighted by Karen; she's reassuring them they're important to her; "don't despair - you're there - from beginning to middle to end" as well as "my sun is your sun, your sun is our sun." Basically, Karen is saying even if you aren't aware, you're always always always important to me and 'there' in my mind.