Lyric discussion by E4Ducky 

Cover art for Paradigm lyrics by Avenged Sevenfold

I'd wager the song is about a person, naturally fearing death, succumbing to his wishes for immortality. Technology has created a way for immortality to happen, through what seems to be a Matrix-type computer generated consciousness, but by "plugging in" humanity loses something core to them; perhaps a yearning for freedom.

This whole album plays off of the idea of the singularity: an event in which technology gets so advanced and AI's are created. This causes such unimaginable exponential scientific growth that humans become obsolete and are likely to be enslaved by the AI's they've created. The Matrix is an exploration of this event as well SPOILER ALERT: the humans are put into a digital existence and the electricity generated by their perception of reality is used to fuel the AI's ships, etc.