Lyric discussion by queenvictoria 

Cover art for Shots lyrics by Imagine Dragons

I firmly believe that this song is about his failed relationships with people (as agreed by sirlenopow) due to his depression. As a person with depression, it gets harder and harder to maintain a healthy relationship because you don't feel like talking to anyone. As such, he 'shot, shot, shot a hole' through everything he loved by pushing them away and hurting them by doing so.

My Interpretation