Lyric discussion by thelastword 

Cover art for Prozac Rock lyrics by Margot & the Nuclear So and So's

Prozac is prescribed for a number of different psychological problems but in a nutshell, it takes the "edge" off. The song is making a mockery of formulaic, overly focus-grouped, teen-targeting "rock" music about sex, drugs, idealized notions of love ('get in the mood', 'getting high', 'river of roses') with no "edge" or artistic integrity. Well done.