The chorus, at least, seems pretty self-explanatory. Most of the song seems to be about some of his experiences: Lovers rejecting him, people hating him, people loving him to much, hard times, good times. But in the chorus, he says that, in 100 years, none of it will mean anything. No matter how hard he tries to change that, eventually he will be dead and forgotten. No, it won't mean a thing in a hundred years.
The chorus, at least, seems pretty self-explanatory. Most of the song seems to be about some of his experiences: Lovers rejecting him, people hating him, people loving him to much, hard times, good times. But in the chorus, he says that, in 100 years, none of it will mean anything. No matter how hard he tries to change that, eventually he will be dead and forgotten. No, it won't mean a thing in a hundred years.