I think "substitute the anger and aggression with guilt and depression and it's yours" within the context of "white boys" participating in hiphop could be a statement about how mainstream hiphop may have started as something that in part gave voice to the frustrations of the Black experience at the time of its conception, where "guilt and depression" can be associated with the concepts of White guilt and anxieties perceivably pertinent to the [far more privileged] White experience.
I think "substitute the anger and aggression with guilt and depression and it's yours" within the context of "white boys" participating in hiphop could be a statement about how mainstream hiphop may have started as something that in part gave voice to the frustrations of the Black experience at the time of its conception, where "guilt and depression" can be associated with the concepts of White guilt and anxieties perceivably pertinent to the [far more privileged] White experience.