Lyric discussion by jer1030256 

Cover art for Black River Blues lyrics by .357 String Band, The

I think this song might be about a drug addiction.

"There’s a two-lane highway in my mind." - Having to choose drugs or relationships.

"My heart’s divided by white lines." - White lines = Cocaine.

"When the lane I love is the lane takes me further from you" - Being addicted and needing a fix, while harming relationships.

My Interpretation

@jer1030256 Good catch, as highways are divided by yellow lines. Genius song writing.