Lyric discussion by MashedPE 

Cover art for Guns For Hands lyrics by Twenty One Pilots

This is my semi-detailed breakdown:

An interesting thing to note is the happy music with the lyrics about depression. I believe when analyzing the lyrics, he does this because people that carelessly listen to the song will not understand it. It requires deep thought. Depression also requires non depressed people to understand the disorder before they can help. The beginning of the song has to do with depression and self harm and the thoughts of suicide most depressed people constantly have. The 1st part talks about the morning after a night of cutting, and the common lie to loved ones to stop. The 2nd part is obvious. Constant suicidal idealization and going back and forward on the idea of suicide. The 3rd part explains that he is concerned about not just his own depression and suicide, but every one else that's depressed. Now the song becomes more about the lack of help/aid depressed people get. The 5th part is an attempt to let this song be the stepping stone into coming together and start helping this epidemic. It also says that depression wont get better if you become a recluse (you have to take action).
The 8th part (the rap verse) is confusing. I think the first half is specifically aimed at non depressed people and trying to explain to them what the deal is with depression (showing that he also deals with it). In the other half he explains that his lyrics are trying to turn the guns (suicidal thoughts) into fists (to fight their disorder).

This is my opinion! Let me know if you disagree with anything :)

My Interpretation

@MashedPE i agree with everything you said, EXCEPT for the rap verse part. in my opinion, hes saying that he wants the suicidal kids/ people to stop harming themselves and that he rathers that they hurt him, instead of themselves (simply sugest my chest in this confused music) but, hey, this is only my opinion and im just a 7th grader, so i dont know everything, and this is just my opinion/ theory. Hope i helped, though

@MashedPE, I also agree but I also think the rap verse is about how society doesn't help suicidal kids either. They push them around like "mutant kids" and show them the direction to suicide. This speaks to me as bullying or the Laramie Project, in the story of the Laramie Project a boy who is openly gay gets beaten to death by some kids at school. "It's obviously best for them to turn their guns to a fist" see what I mean? The guns are their anger that get transformed into their hands as weapons.

@MashedPE That sounds right, but I think it's also kind of about how much people's actions and words can affect others.