I think this song is about taking a look at your life and assessing all the damage you've done to yourself and to others throughout the course of it. After seeing all the bad you've done you've come to the realisation that it's best to stay away from everything and perhaps everyone so you don't continue hurting them with all your issues. Hence, escaping and letting go, getting straight...cleaning up your act. He asks why'd you have to make this so hard, because it's hard to just cut all ties with your loved ones so easily.
After typing all that, I realised it fits perfectly with the final episode of Dexter.
I think this song is about taking a look at your life and assessing all the damage you've done to yourself and to others throughout the course of it. After seeing all the bad you've done you've come to the realisation that it's best to stay away from everything and perhaps everyone so you don't continue hurting them with all your issues. Hence, escaping and letting go, getting straight...cleaning up your act. He asks why'd you have to make this so hard, because it's hard to just cut all ties with your loved ones so easily.
After typing all that, I realised it fits perfectly with the final episode of Dexter.