Lyric discussion by steveba 

Cover art for Spoonful lyrics by Howling Wolf, The

The reference is to heroin. Blues men were notorious drug users, much like modern musicians who owe their existence to the blues. The lyrics throw in a few stereotypical blues references like shooting a man over your woman, and some of that "precious love" but the gist is heroin. Wolf was the best blues singer ever. In fact one of the best singers ever period.

Song Meaning