The first comment mentioned this, but everyone else is looking for some wider ranging theme. My take has always been that this song is about a relationship, and a bad one at that. The two people in the relationship make each other miserable, yet they can't pull themselves apart. They are so good at making each other miserable (we made the disease), that they might as well try and turn it into a business. They are still hopeful (we'll create a cure), but the singer is recognizing that their misery is so ingrained, it is actually incorporated into their relationship, which is another play on the incorporated aspect. The singer also wants something different (put me out of my misery), but doesn't know how to take the first step (I'd do it for you, would you do it for me). The suicide kings and drama queens line refers to the types of people who enter into these destructive relationships. The forever after is a play on the marriage vows that a couple would take, having committed to their mutual misery without realizing where it would take them. The last verse, "Did you satisfy your greed, get what you need/Was it only envy, so empty," is the singer questioning his partner, whose motives for entering into the relationship might be suspect. Maybe she saw him as a happy person and was envious, but brought out the worst in him. Certainly the repetition of "frustrated, incorporated" seems to make sense in a bad relationship context, where you are committed to a structure, but you have incorporated your sexual frustration into that structure.
The first comment mentioned this, but everyone else is looking for some wider ranging theme. My take has always been that this song is about a relationship, and a bad one at that. The two people in the relationship make each other miserable, yet they can't pull themselves apart. They are so good at making each other miserable (we made the disease), that they might as well try and turn it into a business. They are still hopeful (we'll create a cure), but the singer is recognizing that their misery is so ingrained, it is actually incorporated into their relationship, which is another play on the incorporated aspect. The singer also wants something different (put me out of my misery), but doesn't know how to take the first step (I'd do it for you, would you do it for me). The suicide kings and drama queens line refers to the types of people who enter into these destructive relationships. The forever after is a play on the marriage vows that a couple would take, having committed to their mutual misery without realizing where it would take them. The last verse, "Did you satisfy your greed, get what you need/Was it only envy, so empty," is the singer questioning his partner, whose motives for entering into the relationship might be suspect. Maybe she saw him as a happy person and was envious, but brought out the worst in him. Certainly the repetition of "frustrated, incorporated" seems to make sense in a bad relationship context, where you are committed to a structure, but you have incorporated your sexual frustration into that structure.