Lyric discussion by spid3rpig 

Cover art for Lover to Lover lyrics by Florence + the Machine

These lines sum it all up pretty well

"And I've been taking chances I've been setting myself up for the fall And I've been keeping secrets From my heart and from my soul"

It sounds to me it's about a woman who's been making mistakes, taking different lovers and sabotaging her chances of happiness because she didn't think she deserved it. "keeping secrets from my heart and from my soul" part makes me think that she was in love with someone but didn't want to admit it even to herself. She was afraid to love this person so she sabotaged the relationship.

My Interpretation