Lyric discussion by dirtyhairy 

Cover art for Dark Center of the Universe lyrics by Modest Mouse

I haven't read all the comments, so i could be wrong, but i haven't seen anything too close to my take on it. Isaac says that he is an atheist, but in several songs (Styrofoam boot, the ocean breaths salty, parasites from ugly casanova) god exists as a metaphorical character. In styrofoam boots god is portrayed as just some average every day guy.
This song seems to be god talking to Isaac.
"I might disintrigate into thin air if youd like" if people dont believe in god, then whats the point of him being there? "I'm not the dark center of the universe like you thought" adds to the idea since god is thought of as a entity off in heaven or space.
"I died saying something but I didn't mean it, It took a lot of work to be the ass i am.
And im real damn sure that anyone can equally, easily fuck you over" this shows god as someone who is a shitty person just like the rest of us, while he also is defending himself by saying "woah hold on i did some shitty stuff but im not the dark center of the universe like you thought. "well an endless ocean landing on an endless desert, its funny as hell but no one laughs when they get there" this is about life and death. Our lives are like being lost at sea, hoping to see land (death), but when you finally find it, its just a desert. You were looking for land but the desert is just as bad as the open sea. "well im sure youd tell me you got nothing to say, but our voices shook hands the other day" Voices shaking hands is prayer, and this is god basically telling isaac, "you say you dont believe in me, yet you were praying to me the other day. "if you cant see the thin air, then what the hell is in the way." Heaven and religion is the thin air, and if you cant see the obvious (its not there) then what is in the way? anyway thats my interpretation