Lyric discussion by bumbaklatious 

Cover art for Interlude with Ludes lyrics by Them Crooked Vultures

after listening to the song and researching the drug 'ludes' i think it's pretty clear that josh is the voice of the drug speaking to the person taking it, probably himself. He mentions always being behind you, and smothing you with my love but then goes on to say acid poison and chemicals will be used, suggesting he is the drug, and how 'i'm yours even if you don't want me' suggests he has no choice but to take this drug and the fact that it's used to treat sleep deprivation he says 'sleep deprivation will make you a million..' the drug being the million.

@bumbaklatious I think I agree with you and also with WPSIATWIN. I think the drug is "speaking" to Josh, but that Josh may have gotten in too deep with drugs altogether, causing him to act really weird, and do crazy stuff (see TCV interview where Dave and JPJ are laughing at Josh being on "6 different drugs").

Perhaps it got to the point that Josh was using, but didn't really want to be--or maybe he could see how it was messing up his life--but was more or less trapped in using chemicals to alter his reality more...