Lyric discussion by twicereminded 

This song might be a reference to the book "I Am Legend" by Richard Matheson. Obviously the band gets their name from his novel, but the plot revolves around the main character knowing that everyone he knew is now a vampire. The hero boards himself in his house (Now that I've boarded up my door/ And I'm laying on the floor) and has to listen to the siren calls of his now-transformed neighbor (No I don't need no other friend/ So I will not let you in). Yup.

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