Nothing as It Seems

I think this is clearly about drug use. In the first verse, he's having withdrawal systems. Methadone is used to treat heroin addicts (which Eddie has used before, I believe). The chorus reaffirms this (for me) because he's talking about the little that he needs. As far as the "uninvited chromosome", I think he is referring to getting his drug addiction from his parents...same with the chip of the cornerstone line. The "blanket like the ozone" bit is about how he can't escape this addiction. He's constantly covered by it. I think "saving up a sunny day" is him waiting to use until he gets depressed again, perhaps? The "one way ticket headstone" seems to mean that he knows that this is going to kill him...but he just can't help it. I'm going through the same thing...maybe that's how I made it make sense to me. That's one of the great things about Pearl Jam though...anyone is capable of relating their lyrics to instances in our own lives. Pearl Jam is just a fantastic band. I'm glad they've stuck around for song.