Signs of the Zodiac Lyrics

Lyric discussion by notebooks 

Cover art for Signs of the Zodiac lyrics by Rasputina

I think this song addresses sickness or possibly bereavement. The affected person believes their sad fate was predestined: they've given up on getting well or getting over their grief. While their friends try to show support, their words ring hollow ("this will really work" has an aura of desperation). They can't make the pain disappear, and sometimes make it worse. In the end they can only know it hurts.