Lyric discussion by ayyamana 

Cover art for Science Is Real lyrics by They Might Be Giants

This song is obviosly about a man who is desperately trying to find love. He illudes to love using the word science. As we all know, chemistry is both a science and a way of saying love and interaction.

He furthers his point by emphasizing fairy tales, in which most end with a marriage.

He places together autonomy and geology to point out how he is placed in a position where the two contradict each other. His city is constantly being bombarded with "knowledge" causing "earthquakes" that break his heart preventing him from commuting certain "Autonomacal" operations.

Towards the end, he speculates that his love for a certain female is not a guess, or a hunch, but a fact. He, in the end, is surprised at love being true, by overly emphasizing "Science is real."

All in all, it shows, to a broader audience, that anything is possible if you only follow your heart.