Lyric discussion by myse1f 

Cover art for Descending lyrics by Black Crowes, The

The chorus makes me wonder.

"Curses Curses and clues Just a feast, feast for fools"

If the song is about drug addiction, then 'the fest of fools' might be a symbol of empty hedonism present in addict's lifestyle. What about "curses and clues"? Is related to constant frustation while seeking a way to get clean? Any other idea people? Also, to bring up some discussion, I've heard that the song may be about Chris' bi-polar tendencies.

Chris is a wierd lyricst. He can write some fantastic stuff(like this one), but also complete shit. Anyway, Crowes are a great band.

Yes, I agree: about addiction, def, and most likely heroin.

"I'm descending again" Means either "descending into addiction," or that he's getting high on a "downer" type drug.

The second verse, with "hand me downs/hand me ups" suggests we're talking about a drug w/ "downer" effects.

Sounds like a song about someone who traded in a speed addiction for a heroin addiction.