Lyric discussion by benj30a4 

Cover art for Iron Gland lyrics by Alice in Chains

I don't have much knowledge about drug use, period, but maybe he is referring to some kind of effect of or to some kind of gland or another, as the result of drug use. Maybe they are referring to the abnormal usage of the pineal or adrenal glands? I believe meth shuts down your pineal glands, which secretes melatonin, which would allow the user to stay up for days or weeks on end. But I don't know, it's pretty much speculation, since I don't know enough about the use of hard drugs that rock stars typically use.