Lyric discussion by shockm 

Cover art for She Knows lyrics by Gnarls Barkley

He's reflecting on the death of his mother. Cee-Lo, like most all of us, was "living a lie" and his mother was trying to get to him and live life the right way. With the passing of his mother, he is now living the life his mom wanted and is "so much more". Essentially, this is because Cee-lo truly believes his mother is now always with him and is now essentially given a second life through him (what's one to sacrifice when you live more than twice). So, he is essentially possessed by the spirit of his mother (in a good way-like how we are told as kids when someome close dies that they are always with us and watching over us). So, even though he never lived life how his mother wanted him to when she was living, he knows that "she knows" he has now become the man she always wanted him to be.