Lyric discussion by uhcougar 

Cover art for Murder 101 lyrics by Wallflowers, The

I tend to agree with the first comment on this song

"I always thought I knew enough/I didn't want to learn this stuff/I didn't ever want to be that tough/But love was just implied/And everything else died"

Here the subject is claiming that he thought he knew enough about love, but what he knew was the romantic view of it. He didnt want to learn the bad side of love. This might be a little bit of a blind stab, but to me "Murder 101" is a metaphor for learning of heartache, breakup, and despair when it comes to love.

"You can learn it in the first degree/You could even make yourself believe/That you'll never even think of me/When you're packing up your things to leave"

Here he seems to be talking about a previous lover who left him, and that this person is learning some of the material for "Murder 101"

"Find yourself another heart that needs a rest/Tie a hook onto a single thread/Drop it down beneath the chest/There's the first part of this test"

Here the author seems to be explaining to his former lover how to continue to be a better heart breaker and pass "Murder 101." By finding another heart that has been battered, and becoming attached to that new person just as the author was attached to this person.

"Drop out before they come/To Murder one by one"

All I can figure from this is that he is telling me people to avoid these people while you can. If you do not these heart-breakers will "murder" one's idea of love one-by-one.