Lyric discussion by ewot 

Cover art for Give The Mule What He Wants lyrics by Queens of the Stone Age

mules are known to be stubborn, right? The mule wants it, determined to get it, and eat it. Whatever it is, I dunno. I think it's just about stubborn-ass people.

At the end it says for your love, be the mule you gotta be. You need to be a mule and stubborn to get what you want, and in this case love.