Lyric discussion by Rakoth 

Cover art for Up On The Roof lyrics by Les Claypool's Fearless Flying Frog Brigade

I am on board with plenty of what omkarma said. The verses are cravings, the chorus is getting high, or indulging in whatever your addiction is. I think the ladder line has two meanings. A desire to get back up and keep using whatever you're using; also, a desire to be able to get back down, the good ol' "one last hit" mentality. Don't let this be the one too many.

Maybe I'm stretching.