Lyric discussion by mchertron 

Cover art for Misfits lyrics by Third Eye Blind

I believe Jenkins may be referring to a passage by Jack Kerouac. Otherwise, he's talking about his fans and the special people they are. Nerds, misfits, loudmouths, people that like to keep away from the norm.

"Here's to the crazy ones. The misfits. The rebels. The troublemakers. The round heads in the square holes. The ones who see things differently. They're not fond of rules and they have no respect for the status quo. You can quote them, disagree with them, glorify them, or vilify them. But the only thing you can't do is ignore them. Because they change things. They push the human race forward. And some may see them as the crazy ones, we see genius. Because the people who are crazy enough to think they can change the world are the ones who do." — Jack Kerouac