He's talking about how easy it is to die, and how it happens to everyone since we are all nothing more then "Flesh 'n' Blood," and it ends up being the ultimate equalizer. But he's not going to give up to death without a fight, no matter how tempting and also about how his loved can help keep him strong.
"Not going to give up the ghost" means he's not going to give up to death.
He's talking about how easy it is to die, and how it happens to everyone since we are all nothing more then "Flesh 'n' Blood," and it ends up being the ultimate equalizer. But he's not going to give up to death without a fight, no matter how tempting and also about how his loved can help keep him strong.
"Not going to give up the ghost" means he's not going to give up to death.