Lyric discussion by Quartermain 

Cover art for Red House lyrics by Jimi Hendrix Experience, The

The song is about his high school sweet heart, Betty Jean. He named his first guitar after her. Also, her house was actually Brown but Jimi knew "Brown House" isn't a very appealing title. He's talking about how when he came back from the war and she was gone. He's being sarcastic when he talks about her sister.