Maybe it is a song about obsession. There is a girl he really doesn't like, but for some reason she is just in love with him. She thinks he has all the mystery of beauty of Michelangelo's Sistine Chapel painting. Yet she is on his skin (or she annoys him). Still, the more she obsesses over him the more he realizes maybe he just doesn't want to like her because of that. I think in the end he realizes that he does in deed like her as well (she is on his mind).
Maybe it is a song about obsession. There is a girl he really doesn't like, but for some reason she is just in love with him. She thinks he has all the mystery of beauty of Michelangelo's Sistine Chapel painting. Yet she is on his skin (or she annoys him). Still, the more she obsesses over him the more he realizes maybe he just doesn't want to like her because of that. I think in the end he realizes that he does in deed like her as well (she is on his mind).