Well, in an interview she did with "The Advocate," Karen O was asked if the song was about a girl crush, and she responded, "That song wasn’t about a particular girl. When I first started writing songs, the subject (the person I was singing about or to) would be a girl. But there are two types of girls I get crushes on. One is the sort of girl who’s really got it together and who has a sort of boyish look and who’s really got it going on. And then the other is the blond cheerleader type who has like a lip ring or something like that but yet is still just clueless."
Well, in an interview she did with "The Advocate," Karen O was asked if the song was about a girl crush, and she responded, "That song wasn’t about a particular girl. When I first started writing songs, the subject (the person I was singing about or to) would be a girl. But there are two types of girls I get crushes on. One is the sort of girl who’s really got it together and who has a sort of boyish look and who’s really got it going on. And then the other is the blond cheerleader type who has like a lip ring or something like that but yet is still just clueless."
In case you're interested: http://www.advocate.com/issue_story_ektid29865.asp