Lyric discussion by just_old_light 

Cover art for Ave Maria lyrics by Regina Spektor

From what I could gather, it's a call to return to nature.

The boy is an artist who thinks unconventionally and longs for nature. People alternately laugh at his ideas and implore him to stop his train of thought, begging him to stop dreaming about returning to mankind's roots, telling him it's a pointless, unproductive way to think. He should be doing something practical, like learning a new language or holding down a steady job in an office. He turns to prayer for comfort and support, talks to God and Mary because no one else seems to understand him.