Lyric discussion by helloagain3 

Cover art for Sister (New) lyrics by Dave Matthews Band

This song is about Jane, Dave's younger sister. It's not about Anne, his sister who was murdered. Some think it is a tribute to Anne because there are few songs that actually are tributed to her. But the album "Remember Two Things" is actually a tribute to Anne. And this song, is dedicated specifically to Jane like those who said it before. Dave was having trouble writing some new material, and he referred to Jane for some help in which she told him to "Get your head out of your ass." This song is the result of Dave pulling his head out, and wrote a beautiful song in honor of his Sister Jane.