Lyric discussion by sheisthenewthing 

Cover art for Trouble lyrics by Ray LaMontagne

i actually have two interpretation so this song the first is that its about drug addiction and his female friend helped him through that and stuck by him when no1 else woild and worried about him "swear it feels like this worry is my only friend" i think where he uses the word worry there he means her.I think hes always had an addictive personality where he says"Been doggin' my soul since the day I was born"and that after he beat his addiction with her help he realised hes in love with her and his new addiction has become her."Feels like every time I get back on my feet She come around and knock me down again"

2.)my second interpretation is that hes referring to the character being a transvestite."Trouble Been doggin' my soul since the day I was born"i think hes always known he was different and its come to the stage where he just has to be himself and in a snese save himself from himself.The woman hes referring to could be himself as he wants to be as hes thinks being a woman would "save" him.with lines such as "Feels like every time I get back on my feet She come around and knock me down again" i feel when hes being a woman his exterior gets him into trouble just as hes ajusting to it in a way the woman could also be his mother who knows hes a transvestite and wants to protect him"She won't let me go" in way the woman he keeps referring to could be an immersion of himself and his mother.