Lyric discussion by Giffdud 

Cover art for Sugar Will lyrics by Dave Matthews Band

Here are the lyrics as best as i could get from the Golden Gate Park Concert cd with Santana:

so what is it? in the middle of this came in to save us oh red was staining and covering, oh I wonder called all this for myself wonder if you knew

sugar ain't poison but sugar will kill you too much of a good thing maybe not so sweet

what do you think about that?

I came in, maybe, bit too late and stinking, you said of something holy and either way to solve this, really matters oh drumming out try to find for myself whatever come rain empty space, I fell for myself I wonder if you knew

sugar ain't poison but sugar will kill you too much of a good thing maybe not so sweet

what do you know about that?

And all of a sudden you were screaming came scratching in, love, all of these Oh, I thought, must be dreaming it's not like you but oh then I've done it all by myself still it seems surprising, oh then broke the wall by myself still wonder how you knew

sugar ain't poison but sugar will kill you too much of a good thing maybe not so sweet

I think it has to do with relationships. Too much of a good thing maybe not so sweet is realizing that what he thought would make him happy (or make the other person happy) is really not what that person needed.