Lyric discussion by BlueMonkey 

Cover art for Reno lyrics by Bruce Springsteen

There are a few things to take into consideration when analyzing the meaning of this song. First off, in a nutshell, it is about a man who finds himself having sex with a prostitute in a Reno hotel room. The first part of the song is pretty obvious, as they negotiate a deal and she begins to perform oral sex on him. We get the first indication that something isn't right with the lyric "My eyes drifted out the window and down to the road below". Here is this quite probably beautiful woman performing an intimate act on him, and yet his attention his elsewhere. Where? The Boss then tells us in the second part of the song..."Sunlight on the Amatitlan...we rode with the vaqueros...sunlight streaming through your hair". He is daydreaming, drifting away to thoughts and memories of another woman, possibly a wife or longterm partner. Perhaps she has died or they let their love slip away. While the prostitute continues her act, all the protagonist can think about our precious moments and images shared with his true love. We then return to the hotel room and they have sex. Later, the prostitute toasts him with a whiskey and congratulates him on the "best you ever had". The protagonist simply smiles to himself and admits that it wasn't the best, it didn't compare to the love and passion he shared with his love. Sex with the prostitude is "not even close" to what he shared previously with Maria.

As many of us know, the art of making love and experiencing satisfing, fulfilling sex is only 10% physical and 90% mental/emotional. The protagonist does not have his heart and mind in the hotel room...the sex is a cold, clinical physical act..and at the end of it, he is left with an empty, hollow feeling of loss, regret and void for Maria.

@BlueMonkey Mr overthinking !