It could be about the mother from Ghost of Perdition.
In my previous posts on some songs from Ghost Reveries, I argue that the woman is in fact giving birth to the son of the devil.
Isolation Years might be about that son grieving over the death of his mother, who dies because of her pact with the devil.
Satan might have promised her eternal life or something, but then she died anyway, he could not save her.
It could be about the mother from Ghost of Perdition. In my previous posts on some songs from Ghost Reveries, I argue that the woman is in fact giving birth to the son of the devil.
Isolation Years might be about that son grieving over the death of his mother, who dies because of her pact with the devil. Satan might have promised her eternal life or something, but then she died anyway, he could not save her.