Lyric discussion by acidsex 

Cover art for Running From An Angel lyrics by Hootie & the Blowfish

I always felt this was about his dad and drug addiction.

"Sometimes we’d laugh and talk, seems like yesterday Then you let the white horse come and take you away "

Cocaine addiction.

"They came to get you, it was cold and black The wheels were in motion, there was no turning back "

Over dosing.

"Your lying and cheating really tore us apart Please don’t come home if you’re gonna break my momma’s heart "

I interpert that as he is telling his dad dont come home if he isnt clean because it will only break his mothers heart.