Lyric discussion by donnas 

Cover art for Little Sister lyrics by Rufus Wainwright

I may be very wrong but to me this song is about the professional rivalry along with the fact that Rufus as a boy/male will get more attention, more promotion etc... Basicaly Rufus is acknowledging his sisters talent but saying that they shouldn't let rivalries get in the way of their relationship, rather accept that he will be favoured as the talent until the time that her genius is recognised.

Maybe he is saying 'so long as we know that you are as talented then lets not let it break us apart as brother and sister'