Lyric discussion by Mourningstar74 

Cover art for Wet My Eyes lyrics by Stone Temple Pilots

I don't think the meaning of this song is overly deep...

The music is trippy, and it sounds like he's pretty stoned. He got ready for Mary to come over and spend the night and she's missing. She's probably off somewhere too messed up on drugs to move--->"check the bathroom"

At the end he's just too messed up to comprehend what's going on.

Obvious reference here---> "water cleanses" talking about baptism.