Once In A Lifetime

i think its a little simplistic to say that this song is just about appreciating what you have...

for one, pay attention to the delivery of the verses in contrast to the chorus. the verses are delivered like a sermon, then the chorus comes in like the choir. the character speaking is describing a sort of life process where people don't ask questions, where they blindly follow a certain path in life, getting a job, getting a wife, getting a car, without stopping to ask if this is what will make them happy. so byrne is comparing people who oversimplify and don't question their own life choices with people who blindly follow religions without questioning if its the right path for them or not.