Lyric discussion by deenfoxx 

Cover art for Destination Moon lyrics by They Might Be Giants

The card with the cartoon nurse is obviously a get well card, implying an illness. To me, this song is about a person determined to travel to the moon, taking necessary steps along the way and dealing with people who keep telling him he's crazy or wasting his life. The last part shows that he has continued his attempt throught his life and is on his last legs, but still determined to make it a reality.