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Tool – Forty Six & 2 Lyrics 6 years ago
"Everyone carries a shadow, and the less it is embodied in the individual's conscious life, the blacker and denser it is. It may be (in part) one's link to more primitive animal instincts, which are superseded during early childhood by the conscious mind." - Jung

The song is about Jung's Psychological theory of the "Shadow."

And yes, it does have something to do with Chromosomes- Jung said that it is "One's link to more primitive animal instincts.." Humans have 46 chromosomes. Apes have 48.
46 + 2 = 48

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