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Eels – The Medication Is Wearing Off Lyrics 23 years ago
I think the song is actually about his mother. Both she and E's sister passed away when E started writing this album. The only reason I say it's about his mother and not his sister is the line "break your mothers heart". Also, E's sister was a huge part of how he got into music, so I would think he would use some type of musical object as a gift from her.

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