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Amanda Palmer – Runs in the Family Lyrics 17 years ago
It sounds like genetics to me. She talks about all of these hereditary illnesses. The lines about sex seem to concern anxiety over passing on bad genes. Any instance of "family" can be replaced with "genes". She can run from many things in life, even true family, but one can't very effectively run from their genetic makeup.

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Jem – They Lyrics 19 years ago
The video supports the 'government' interpretation, but without that it fits perfectly as a comment on religion.

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