Lyric discussion by jddunlap 

I was at the debut concert for the Smoke+Mirrors tour last night, and Dan talked about how for him personally, this song was about living with health problems (he spoke about his night blindness, ulcerative colitis, etc) - and presumably about pursuing his goals and shaping his world the way he dreams it could be in spite of them.

As for the wider, more general meaning, I would go with pedro5qd's interpretation.

@jddunlap I should say "the North American debut" since I think they did a few concerts outside of North America to test out.

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