Holy shit I love proteomics! I could just cry, I feel so understood. Reality is a fantastically complex space of highly derived systems relentlessly spawning beauty and spewing vitriol as per their chemical constituents! It's all very lovely to me, this experience of scientific understanding and the confounding effect it has on meaning...
For anyone that doesn't know, and is interested, C.R.E.B. = CREB1, the human gene encoding for the cAMP responsive element binding protein 1, which is a transcription factor that binds to specific DNA sequences and induces transcription of downstream target sequences as initiated by hormones interacting with the cyclic AMP pathway. Researchers refer to experimental subjects that have had the gene of interest mutated or deleted as "knockouts": this is the most straightforward way to understand the functions of proteins whose code lies in the gene. You can thank these little dudes (the creb proteins, among others) for allowing you to perceive and interact with reality. This shit is no joke and/or metaphor! Source: ncbi.nlm.nih.gov/pubmed/9530494
Holy shit I love proteomics! I could just cry, I feel so understood. Reality is a fantastically complex space of highly derived systems relentlessly spawning beauty and spewing vitriol as per their chemical constituents! It's all very lovely to me, this experience of scientific understanding and the confounding effect it has on meaning...
For anyone that doesn't know, and is interested, C.R.E.B. = CREB1, the human gene encoding for the cAMP responsive element binding protein 1, which is a transcription factor that binds to specific DNA sequences and induces transcription of downstream target sequences as initiated by hormones interacting with the cyclic AMP pathway. Researchers refer to experimental subjects that have had the gene of interest mutated or deleted as "knockouts": this is the most straightforward way to understand the functions of proteins whose code lies in the gene. You can thank these little dudes (the creb proteins, among others) for allowing you to perceive and interact with reality. This shit is no joke and/or metaphor! Source: ncbi.nlm.nih.gov/pubmed/9530494
annualreviews.org/doi/abs/10.1146/annurev.neuro.21.1.127
annualreviews.org/doi/abs/10.1146/annurev.neuro.21.1.127
@kirs10 thank you
@kirs10 thank you